Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice

Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice

Abstract Decreased estrogens during menopause are associated with increased risk of anxiety, depression, type 2 diabetes and obesity. Similarly, depleting estrogens in rodents by ovariectomy, combined with a high-fat diet (HFD), increases anxiety and adiposity. How estrogens and diet interact to aff...

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Bibliographic Details
Main Authors: Kalpana D. Acharya, Madeline Graham, Harshini Raman, Abigail E. R. Parakoyi, Alexis Corcoran, Merzu Belete, Bharath Ramaswamy, Shashikant Koul, Ishneet Sachar, Kevin Derendorf, Jeremy B. Wilmer, Srikanth Gottipati, Marc J. Tetel
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-31783-6

Internet

https://doi.org/10.1038/s41598-023-31783-6

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