α-MSH-induced activation of spinal MC1R but not MC4R enhances colorectal motility in anaesthetised rats

Abstract The central nervous system is involved in regulation of defaecation. It is generally considered that supraspinal regions control the spinal defaecation centre. However, signal transmission from supraspinal regions to the spinal defaecation centre is still unclear. In this study, we investig...

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Bibliographic Details
Main Authors: Hiromi H. Ueda, Kiyotada Naitou, Hiroyuki Nakamori, Kazuhiro Horii, Takahiko Shiina, Tatsunori Masatani, Mitsuya Shiraishi, Yasutake Shimizu
Format: Article
Language:English
Published: Nature Portfolio 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-80020-x