DFP-Induced Status Epilepticus Severity in Mixed-Sex Cohorts of Adult Rats Housed in the Same Room: Behavioral and EEG Comparisons

DFP-Induced Status Epilepticus Severity in Mixed-Sex Cohorts of Adult Rats Housed in the Same Room: Behavioral and EEG Comparisons

Sex is a biological variable in experimental models. In our previous diisopropylfluorophosphate (DFP) studies, female rats required a higher dose of DFP to achieve a somewhat similar severity of status epilepticus (SE) as males. In those studies, male and female rats were bought separately from the...

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Bibliographic Details
Main Authors: Nikhil S. Rao, Christina Meyer, Suraj S. Vasanthi, Nyzil Massey, Manikandan Samidurai, Meghan Gage, Marson Putra, Aida N. Almanza, Logan Wachter, Thimmasettappa Thippeswamy
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
sex as a biological variable
midazolam
telemetry
organophoshate
status epilepticus
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.895092/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.895092/full

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