Visualizing mitochondrial heme flow through GAPDH in living cells and its regulation by NO

Visualizing mitochondrial heme flow through GAPDH in living cells and its regulation by NO

Iron protoporphyrin IX (heme) is a redox-active cofactor that is bound in mammalian cells by GAPDH and allocated by a process influenced by physiologic levels of NO. This impacts the activity of many heme proteins including indoleamine dioxygenase-1 (IDO1), a redox enzyme involved in immune response...

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Bibliographic Details
Main Authors: Pranjal Biswas, Joseph Palazzo, Simon Schlanger, Dhanya Thamaraparambil Jayaram, Sidra Islam, Richard C. Page, Dennis J. Stuehr
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Redox Biology
Subjects:
Heme protein
Mitochondria
Hsp90
Heme trafficking
GAPDH
IDO1
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172400096X

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http://www.sciencedirect.com/science/article/pii/S221323172400096X

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