Increased chromosomal instability characterizes metastatic renal cell carcinoma

Increased chromosomal instability characterizes metastatic renal cell carcinoma

The evolutionary trajectories of treatment-naïve metastatic tumour are largely unknown. Such knowledge is crucial for cancer prevention and therapeutic interventions. Herein, we performed whole genome or exome sequencing of 19 tumour specimens and 8 matched normal kidney tissues from 8 clear cell re...

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Bibliographic Details
Main Authors: Qin Ma, Jilu Wang, Jie Qi, Ding Peng, Bao Guan, Jianye Zhang, Zhongwu Li, Hongxian Zhang, Ting Li, Yue Shi, Xuesong Li, Liqun Zhou, Ke Chen, Weimin Ci
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Translational Oncology
Subjects:
Clear cell renal cell carcinoma
Metastasis
Evolutionary trajectory
Somatic copy number alteration
Loss of heterozygosity
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320304216

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http://www.sciencedirect.com/science/article/pii/S1936523320304216

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