Genetic landscape of T cells identifies synthetic lethality for T-ALL

Genetic landscape of T cells identifies synthetic lethality for T-ALL

Abstract To capture the global gene network regulating the differentiation of immature T cells in an unbiased manner, large-scale forward genetic screens in zebrafish were conducted and combined with genetic interaction analysis. After ENU mutagenesis, genetic lesions associated with failure of T ce...

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Bibliographic Details
Main Authors: Connor P. O’Meara, Lucia Guerri, Divine-Fondzenyuy Lawir, Fernando Mateos, Mary Iconomou, Norimasa Iwanami, Cristian Soza-Ried, Katarzyna Sikora, Iliana Siamishi, Orlando Giorgetti, Sarah Peter, Michael Schorpp, Thomas Boehm
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02694-x

Internet

https://doi.org/10.1038/s42003-021-02694-x

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