Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer’s disease

Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer’s disease

Abstract Background The interaction between the brain and periphery might play a crucial role in the development of Alzheimer’s disease (AD). Methods Using blood transcriptomic profile data from two independent AD cohorts, we performed expression quantitative trait locus (cis-eQTL) analysis of 29 si...

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Bibliographic Details
Main Authors: Young Ho Park, Jung-Min Pyun, Angela Hodges, Jae-Won Jang, Paula J. Bice, SangYun Kim, Andrew J. Saykin, Kwangsik Nho, for the AddNeuroMed consortium and the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Transcriptome
Blood
Expression quantitative trait locus
Genome-wide association study
Expression
Online Access:https://doi.org/10.1186/s13195-021-00919-z

Internet

https://doi.org/10.1186/s13195-021-00919-z

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