Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors

Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors

HIV-1 accessory proteins Nef and Vpu enhance viral pathogenesis through partially overlapping immune evasion activities. Attenuated Nef or Vpu functions have been reported in individuals who display slower disease progression, but few studies have assessed the relative impact of these proteins in no...

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Bibliographic Details
Main Authors: Gisele Umviligihozo, Jaclyn K. Mann, Steven W. Jin, Francis M. Mwimanzi, Hua-Shiuan A. Hsieh, Hanwei Sudderuddin, Guinevere Q. Lee, Helen Byakwaga, Conrad Muzoora, Peter W. Hunt, Jeff N. Martin, Jessica E. Haberer, Etienne Karita, Susan Allen, Eric Hunter, Zabrina L. Brumme, Mark A. Brockman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Virology
Subjects:
HIV non-progressors
viral accessory proteins
immune evasion
pathogenesis
downregulation
CD4
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2022.917902/full

Internet

https://www.frontiersin.org/articles/10.3389/fviro.2022.917902/full

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