Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection

Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection

Chikungunya virus (CHIKV) infection causes intense cytokine/chemokine inflammatory responses and debilitating joint pain. Indoleamine2,3–dioxygenase 1 (IDO-1) is an enzyme that initiates the tryptophan degradation that is important in initial host innate immune defense against infectious pathogens....

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Bibliographic Details
Main Authors: Thiara Manuele Alves de Souza, Caroline Fernandes-Santos, Jéssica Araújo da Paixão de Oliveira, Larissa Cristina Teixeira Tomé, Victor Edgar Fiestas-Solórzano, Priscila Conrado Guerra Nunes, Gabriel Macedo Costa Guimaraes, Juan Camilo Sánchez-Arcila, Iury Amâncio Paiva, Luís Jose de Souza, Paulo Vieira Damasco, Válber da Silva Frutuoso, Manoela Heringer, Luzia Maria de Oliveira-Pinto, Roberta Olmo Pinheiro, Flavia Barreto dos Santos, Elzinandes Leal de Azeredo
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pathogens
Subjects:
chikungunya
indoleamine 2,3-dioxygenase 1
cytokines
chemokines
Online Access:https://www.mdpi.com/2076-0817/11/4/444

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https://www.mdpi.com/2076-0817/11/4/444

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