Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade

Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade

Abstract Sustained inflammatory invasion leads to joint damage and progressive disability in several autoimmune rheumatic diseases. In recent decades, targeting M1 macrophage polarization has been suggested as a promising therapeutic strategy for autoimmune arthritis. P300/CBP-associated factor (PCA...

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Bibliographic Details
Main Authors: Jinteng Li, Feng Ye, Xiaojun Xu, Peitao Xu, Peng Wang, Guan Zheng, Guiwen Ye, Wenhui Yu, Zepeng Su, Jiajie Lin, Yunshu Che, Zhidong Liu, Pei Feng, Qian Cao, Dateng Li, Zhongyu Xie, Yanfeng Wu, Huiyong Shen
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Nanobiotechnology
Subjects:
PCAF
M1 polarization
Macrophage
Autoimmune arthritis
Dextran sulfate-based nanoparticles (DSNPs)
Online Access:https://doi.org/10.1186/s12951-023-02012-z

Internet

https://doi.org/10.1186/s12951-023-02012-z

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