Teenage-Onset Colorectal Cancers in a Digenic Cancer Predisposition Syndrome Provide Clues for the Interaction between Mismatch Repair and Polymerase δ Proofreading Deficiency in Tumorigenesis

Teenage-Onset Colorectal Cancers in a Digenic Cancer Predisposition Syndrome Provide Clues for the Interaction between Mismatch Repair and Polymerase δ Proofreading Deficiency in Tumorigenesis

Colorectal cancer (CRC) in adolescents and young adults (AYA) is very rare. Known predisposition syndromes include Lynch syndrome (LS) due to highly penetrant <i>MLH1</i> and <i>MSH2</i> alleles, familial adenomatous polyposis (FAP), constitutional mismatch-repair deficiency...

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Bibliographic Details
Main Authors: Esther Schamschula, Miriam Kinzel, Annekatrin Wernstedt, Klaus Oberhuber, Hendrik Gottschling, Simon Schnaiter, Nicolaus Friedrichs, Sabine Merkelbach-Bruse, Johannes Zschocke, Richard Gallon, Katharina Wimmer
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Biomolecules
Subjects:
digenic
colorectal cancer (CRC) in adolescents and young adults (AYA)
POL-LYNCH
Lynch syndrome (LS)
polymerase proofreading (PP)
Pol δ
Online Access:https://www.mdpi.com/2218-273X/12/10/1350

Internet

https://www.mdpi.com/2218-273X/12/10/1350

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