Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways

Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways

Although there are many therapeutic strategies such as surgery and chemotherapy, the prognosis of osteosarcoma (OS) is still far from being satisfactory. It is urgent to develop more effective, tolerable and safe drugs for the treatment of OS. In the present study, we investigated the anti-OS activi...

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Bibliographic Details
Main Authors: Chunmei Yang, Lulu Zhang, Huakun Huang, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Yanran Huang, Xiaoji Luo, Jinyong Luo
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-03-01
Series:Genes and Diseases
Subjects:
Alantolactone
ERK1/2
JNK
Mitogen activated protein kinases
Osteosarcoma
p38
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304220300970

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http://www.sciencedirect.com/science/article/pii/S2352304220300970

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