Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines

Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines

Abstract To determine whether muscle disuse after a spinal cord injury (SCI) produces elevated markers of cellular senescence and induces markers of the senescence‐associated secretory phenotypes (SASPs) in paralyzed skeletal muscle. Four‐month‐old male Sprague‐Dawley rats received a moderate‐severe...

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Bibliographic Details
Main Authors: Zachary A. Graham, Abigail Goldberger, Daniella Azulai, Christine F. Conover, Fan Ye, William A. Bauman, Christopher P. Cardozo, Joshua F. Yarrow
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Physiological Reports
Subjects:
cytokines
inflammation
paralysis
SASP
senescence
spinal cord injury
Online Access:https://doi.org/10.14814/phy2.14357

Internet

https://doi.org/10.14814/phy2.14357

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