The immunoregulatory role of monocytes and thrombomodulin in myelodysplastic neoplasms

Myelodysplastic neoplasms (MDS) are clonal disorders of the myeloid lineage leading to peripheral blood cytopenias. Dysregulation of innate immunity is hypothesized to be a potent driver of MDS. A recent study revealed increased thrombomodulin (TM) expression on classical monocytes in MDS, which was...

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Bibliographic Details
Main Authors: Luca L. G. Janssen, Nathalie van Leeuwen-Kerkhoff, Theresia M. Westers, Tanja D. de Gruijl, Arjan A. van de Loosdrecht
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1414102/full