c-Mpl-del, a c-Mpl alternative splicing isoform, promotes AMKL progression and chemoresistance

c-Mpl-del, a c-Mpl alternative splicing isoform, promotes AMKL progression and chemoresistance

Abstract Acute megakaryocytic leukemia (AMKL) is a clinically heterogeneous subtype of acute myeloid leukemia characterized by unrestricted megakaryoblast proliferation and poor prognosis. Thrombopoietin receptor c-Mpl is a primary regulator of megakaryopoeisis and a potent mitogenic receptor. Aberr...

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Bibliographic Details
Main Authors: Fei Li, Yuanyan Xiong, Mo Yang, Peiling Chen, Jingkai Zhang, Qiong Wang, Miao Xu, Yiming Wang, Zuyong He, Xin Zhao, Junyu Huang, Xiaoqiong Gu, Li Zhang, Rui Sun, Xunsha Sun, Jingyao Li, Jinxin Ou, Ting Xu, Xueying Huang, Yange Cao, Xiaohong Ruby Xu, Danielle Karakas, June Li, Heyu Ni, Qing Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05315-5

Internet

https://doi.org/10.1038/s41419-022-05315-5

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