Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes

Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes

Abstract Background Excitation/inhibition (E/I) imbalance remains a widely discussed hypothesis in autism spectrum disorders (ASD). The presence of such an imbalance may potentially define a therapeutic target for the treatment of cognitive disabilities related to this pathology. Consequently, the s...

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Bibliographic Details
Main Authors: Joana Gonçalves, Inês R. Violante, José Sereno, Ricardo A. Leitão, Ying Cai, Antero Abrunhosa, Ana Paula Silva, Alcino J. Silva, Miguel Castelo-Branco
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Molecular Autism
Subjects:
Autism spectrum disorders
Neurofibromatosis type 1
Excitation/inhibition imbalance
GABA(A) receptor
Magnetic resonance spectroscopy
Online Access:http://link.springer.com/article/10.1186/s13229-017-0166-4

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http://link.springer.com/article/10.1186/s13229-017-0166-4

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