Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products

Over-regulation of Heme oxygenase 1 (HO-1) has been recently identified in many types of human cancer, and in these cases, poor clinical outcomes are normally reported. Indeed, the inhibition of HO-1 is being considered as an anticancer approach. Imidazole scaffold is normally present in most of the...

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Bibliographic Details
Main Authors: Giuseppe Floresta, Emanuele Amata, Davide Gentile, Giuseppe Romeo, Agostino Marrazzo, Valeria Pittalà, Loredana Salerno, Antonio Rescifina
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Marine Drugs
Subjects:
Online Access:https://www.mdpi.com/1660-3397/17/2/113