Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors.
Homeostatic synaptic plasticity is a negative-feedback mechanism for compensating excessive excitation or inhibition of neuronal activity. When neuronal activity is chronically suppressed, neurons increase synaptic strength across all affected synapses via synaptic scaling. One mechanism for this ch...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-07-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC4077568?pdf=render |