Understanding LAG-3 Signaling

Understanding LAG-3 Signaling

Lymphocyte activation gene 3 (LAG-3) is a cell surface inhibitory receptor with multiple biological activities over T cell activation and effector functions. LAG-3 plays a regulatory role in immunity and emerged some time ago as an inhibitory immune checkpoint molecule comparable to PD-1 and CTLA-4...

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Bibliographic Details
Main Authors: Luisa Chocarro, Ester Blanco, Miren Zuazo, Hugo Arasanz, Ana Bocanegra, Leticia Fernández-Rubio, Pilar Morente, Gonzalo Fernández-Hinojal, Miriam Echaide, Maider Garnica, Pablo Ramos, Ruth Vera, Grazyna Kochan, David Escors
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
LAG-3
immune checkpoint
cancer signaling
immunotherapy
targeted therapy
Online Access:https://www.mdpi.com/1422-0067/22/10/5282

Internet

https://www.mdpi.com/1422-0067/22/10/5282

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