Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice

Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice

Mice with constitutive disruption of the Selenop gene have been key to delineate the importance of selenoproteins in neurobiology. However, the phenotype of this mouse model is exquisitely dependent on selenium supply and timing of selenium supplementation. Combining biochemical, histological, and b...

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Bibliographic Details
Main Authors: Ulrich Schweizer, Eva K. Wirth, Thomas Klopstock, Sabine M. Hölter, Lore Becker, Jackob Moskovitz, Tilman Grune, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Josef Köhrle, Lutz Schomburg
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Redox Biology
Subjects:
Epilepsy
PVALB
Selenoprotein
Brain
Dystonia
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722002622

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http://www.sciencedirect.com/science/article/pii/S2213231722002622

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