WNT-inhibitory factor 1-mediated glycolysis protects photoreceptor cells in diabetic retinopathy

WNT-inhibitory factor 1-mediated glycolysis protects photoreceptor cells in diabetic retinopathy

Abstract Background In diabetic retinopathy (DR), hypoxia-inducible factor (HIF-1α) induces oxidative stress by upregulating glycolysis. This process leads to neurodegeneration, particularly photoreceptor cell damage, which further contributes to retinal microvascular deterioration. Further, the reg...

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Bibliographic Details
Main Authors: Bolin Chen, Jing Zou, Lihui Xie, Yinjun Cai, Bowen Li, Wei Tan, Jinhaohao Huang, Fangling Li, Huizhuo Xu
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Translational Medicine
Subjects:
Diabetic retinopathy
Photoreceptor cell
Retinal neuronal degeneration
Wnt-inhibitory factor 1
Glycolysis
Online Access:https://doi.org/10.1186/s12967-024-05046-5

Internet

https://doi.org/10.1186/s12967-024-05046-5

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