ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade

ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade

Abstract Despite advances in cancer treatment, immune checkpoint blockade (ICB) only achieves complete response in some patients, illustrating the need to identify resistance mechanisms. Using an ICB-insensitive tumor model, here we discover cisplatin enhances the anti-tumor effect of PD-L1 blockade...

Full description

Bibliographic Details
Main Authors: Xiaolan Liu, Xufeng Cen, Ronghai Wu, Ziyan Chen, Yanqi Xie, Fengqi Wang, Bing Shan, Linghui Zeng, Jichun Zhou, Bojian Xie, Yangjun Cai, Jinyan Huang, Yingjiqiong Liang, Youqian Wu, Chao Zhang, Dongrui Wang, Hongguang Xia
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39920-5

Internet

https://doi.org/10.1038/s41467-023-39920-5

Similar Items