Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate

Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate

Despite major improvements brought about by the introduction of taste-masked formulations of 4-phenylbutyrate (PB), poor compliance remains a significant drawback to treatment for some pediatric and dysphagic patients with urea cycle disorders (UCDs). This study reports on the development of a cyclo...

Full description

Bibliographic Details
Main Authors: Kindness L. Commey, Airi Enaka, Ryota Nakamura, Asami Yamamoto, Kenji Tsukigawa, Koji Nishi, Daisuke Iohara, Fumitoshi Hirayama, Masaki Otagiri, Keishi Yamasaki
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceutics
Subjects:
cyclodextrins
4-phenylbutyrate
orally disintegrating tablets
solid-state complexation
pediatric
Online Access:https://www.mdpi.com/1999-4923/16/1/82

Internet

https://www.mdpi.com/1999-4923/16/1/82

Similar Items