Mechanisms of Disulfide Bond Formation in Nascent Polypeptides Entering the Secretory Pathway

Mechanisms of Disulfide Bond Formation in Nascent Polypeptides Entering the Secretory Pathway

Disulfide bonds are an abundant feature of proteins across all domains of life that are important for structure, stability, and function. In eukaryotic cells, a major site of disulfide bond formation is the endoplasmic reticulum (ER). How cysteines correctly pair during polypeptide folding to form t...

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Bibliographic Details
Main Authors: Philip J. Robinson, Neil J. Bulleid
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
disulfide formation
protein folding
protein secretion
protein synthesis
PDI
ER
Online Access:https://www.mdpi.com/2073-4409/9/9/1994

Internet

https://www.mdpi.com/2073-4409/9/9/1994

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