NLRC4 GOF Mutations, a Challenging Diagnosis from Neonatal Age to Adulthood

NLRC4 GOF Mutations, a Challenging Diagnosis from Neonatal Age to Adulthood

The NLRC4 inflammasome is part of the human immune innate system. Its activation leads to the cleavage of pro-inflammatory cytokines IL-1β and IL-18, promoting inflammation. <i>NLRC4</i> gain-of-function (GOF) mutations have been associated with early-onset recurrent fever, recurrent mac...

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Bibliographic Details
Main Authors: Juliette Bardet, Noémie Laverdure, Mathieu Fusaro, Capucine Picard, Lorna Garnier, Sébastien Viel, Sophie Collardeau-Frachon, Jean-Marie De Guillebon, Isabelle Durieu, Clémence Casari-Thery, Guillaume Mortamet, Audrey Laurent, Alexandre Belot
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Journal of Clinical Medicine
Subjects:
NLRC4
inflammasome
inflammasomopathy
sepsis
autoinflammatory diseases
allergy
Online Access:https://www.mdpi.com/2077-0383/10/19/4369

Internet

https://www.mdpi.com/2077-0383/10/19/4369

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