Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing

Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing

BackgroundMultiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system to which a genetic predisposition contributes. Over 200 genetic regions have been associated with increased disease risk, but the disease-causing variants and their functional impact at the molecular...

Full description

Bibliographic Details
Main Authors: Elena Putscher, Michael Hecker, Brit Fitzner, Nina Boxberger, Margit Schwartz, Dirk Koczan, Peter Lorenz, Uwe Klaus Zettl
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
B cells
genetic disease risk
splicing reporter minigene assay
multiple sclerosis
single-nucleotide polymorphisms
TSFM
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.931831/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.931831/full

Similar Items