Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing

Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing

BackgroundMultiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system to which a genetic predisposition contributes. Over 200 genetic regions have been associated with increased disease risk, but the disease-causing variants and their functional impact at the molecular...

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Bibliographic Details
Main Authors:	Elena Putscher, Michael Hecker, Brit Fitzner, Nina Boxberger, Margit Schwartz, Dirk Koczan, Peter Lorenz, Uwe Klaus Zettl
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Immunology
Subjects:	B cells genetic disease risk splicing reporter minigene assay multiple sclerosis single-nucleotide polymorphisms TSFM
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.931831/full

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