Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

Abstract The maintenance of genomic integrity is essential for normal cellular functions. However, it is difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA damage increases with age and is exacerbated by multiple neurological disorders, including Alzheimer’s dis...

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Bibliographic Details
Main Authors: Niraj M. Shanbhag, Mark D. Evans, Wenjie Mao, Alissa L. Nana, William W. Seeley, Anthony Adame, Robert A. Rissman, Eliezer Masliah, Lennart Mucke
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Astrocytes
DNA damage
53BP1
γH2AX
Neurons
Online Access:http://link.springer.com/article/10.1186/s40478-019-0723-5

Internet

http://link.springer.com/article/10.1186/s40478-019-0723-5

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