Lentiviral in situ targeting of stem cells in unperturbed intestinal epithelium

Lentiviral in situ targeting of stem cells in unperturbed intestinal epithelium

Abstract Background Methods for the long-term in situ transduction of the unperturbed murine intestinal epithelium have not been developed in past research. Such a method could speed up functional studies and screens to identify genetic factors influencing intestinal epithelium biology. Here, we dev...

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Bibliographic Details
Main Authors: George B. Garside, Madeline Sandoval, Slobodan Beronja, K. Lenhard Rudolph
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Biology
Subjects:
Genetic engineering
Microinjection
Intestine
APC
Transduction
Intestinal stem cells
Online Access:https://doi.org/10.1186/s12915-022-01466-1

Internet

https://doi.org/10.1186/s12915-022-01466-1

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