Ray Spier–In Memoriam: Editor's Note: Ray Spier made tremendous contributions to the publication and dissemination of high-quality science. He founded Vaccine in 1983 as the world’s first indexed international journal for this field, which led to the posting of comprehensive vaccine data and information in one major journal for the first time. Ray’s journal blazed the trail for the founding in 2005 of Human Vaccines, now Human Vaccines & Immunotherapeutics. He founded another journal and two societies, notably the International Society for Vaccines in 1996 as an international group that continues to disseminate vaccine data and information through conferences and other venues. In addition, his warmth, charm and attention to ethical issues contributed to his ambassadorial roles. These unique accomplishments placed Ray at the forefront of the vaccines field, and he leaves behind a rich and highly productive legacy for vaccines in the world. His family and friends should feel very proud of his accomplishments and his humanity.