LRP6 High Bone Mass Characterized in Two Generations Harboring a Unique Mutation of Low‐Density Lipoprotein Receptor‐Related Protein 6

LRP6 High Bone Mass Characterized in Two Generations Harboring a Unique Mutation of Low‐Density Lipoprotein Receptor‐Related Protein 6

ABSTRACT Osteoblast Wnt/β‐catenin signaling conditions skeletal development and health. Bone formation is stimulated when on the osteoblast surface a Wnt binds to low‐density lipoprotein receptor‐related protein 5 (LRP5) or 6 (LRP6), in turn coupled to a frizzled receptor. Sclerostin and dickkopf1 i...

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Bibliographic Details
Main Authors: Michael P Whyte, Steven Mumm, Jonathan C Baker, Fan Zhang, Homer Sedighi, Shenghui Duan, Tim Cundy
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:JBMR Plus
Subjects:
BONE DENSITY
BONE MODELING
DICKKOPF1
DXA
ENDOSTEUM
EXOSTOSIS
Online Access:https://doi.org/10.1002/jbm4.10717

Internet

https://doi.org/10.1002/jbm4.10717

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