Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis.

Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis.

Excessive mechanical loading of articular cartilage producing hydrostatic stress, tensile strain and fluid flow leads to irreversible cartilage erosion and osteoarthritic (OA) disease. Since application of high fluid shear to chondrocytes recapitulates some of the earmarks of OA, we aimed to screen...

Full description

Bibliographic Details
Main Authors: Fei Zhu, Pu Wang, Norman H Lee, Mary B Goldring, Konstantinos Konstantopoulos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3012157?pdf=render

Internet

http://europepmc.org/articles/PMC3012157?pdf=render

Similar Items