RNF43 Inactivation Enhances the B‐RAF/MEK Signaling and Creates a Combinatory Therapeutic Target in Cancer Cells

RNF43 Inactivation Enhances the B‐RAF/MEK Signaling and Creates a Combinatory Therapeutic Target in Cancer Cells

Abstract RING finger 43 (RNF43), a RING‐type E3 ubiquitin ligase, is a key regulator of WNT signaling and is mutated in 6–10% of pancreatic tumors. However, RNF43‐mediated effects remain unclear, as only a few in vivo substrates of RNF43 are identified. Here, it is found that RNF43‐mutated pancreati...

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Bibliographic Details
Main Authors: Shih‐Han Hsu, Ya‐Li Tsai, Yeng‐Tseng Wang, Che‐Hung Shen, Yu‐Hsuan Hung, Li‐Tzong Chen, Wen‐Chun Hung
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Advanced Science
Subjects:
B‐RAF
mitogen‐activated protein kinase kinase (MEK)
RING finger protein 43 (RNF43)
Ubiquitin ligases
Wingless and Int‐1 (WNT)
Online Access:https://doi.org/10.1002/advs.202304820

Internet

https://doi.org/10.1002/advs.202304820

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