MiR-155 Dysregulation Is Associated with the Augmentation of ROS/p53 Axis of Fibrosis in Thioacetamide-Induced Hepatotoxicity and Is Protected by Resveratrol

MiR-155 Dysregulation Is Associated with the Augmentation of ROS/p53 Axis of Fibrosis in Thioacetamide-Induced Hepatotoxicity and Is Protected by Resveratrol

Liver fibrosis is a hallmark of thioacetamide (TAA) intoxications. MicroRNAs (miRs), such as miR-155, have been implied in the pathogenesis of liver disease, and regulated by the antioxidant and anti-inflammatory compound resveratrol (RES). The link between reactive oxygen species (ROS), tumour supp...

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Bibliographic Details
Main Authors: Amal F. Dawood, Suliman Al Humayed, Maha A. Momenah, Mohamed El-Sherbiny, Hend Ashour, Samaa S. Kamar, Asmaa M. ShamsEldeen, Mohamed A. Haidara, Bahjat Al-Ani, Hasnaa A. Ebrahim
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Diagnostics
Subjects:
thioacetamide
miR-155
ROS/p53 axis
TIMP-1
α-SMA
liver fibrosis
Online Access:https://www.mdpi.com/2075-4418/12/7/1762

Internet

https://www.mdpi.com/2075-4418/12/7/1762

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