Effects of genetic polymorphisms on methotrexate levels and toxicity in Chinese patients with acute lymphoblastic leukemia

Effects of genetic polymorphisms on methotrexate levels and toxicity in Chinese patients with acute lymphoblastic leukemia

Methotrexate (MTX) has an antitumor effect when used for the treatment of acute lymphoblastic leukemia (ALL). This study aims at evaluating the associations between 14 polymorphisms of six genes involved in MTX metabolism with serum MTX concentration and toxicity accompanying high-dose MTX. Polymorp...

Full description

Bibliographic Details
Main Authors: Qishan Hao, Yang Song, Qiuyun Fang, Yani Lin, Long Chen, Xiaodan Wang, Ping Zhang, Zhe Wang, Xiaoyuan Gong, Kaiqi Liu, Qinghua Li, Zheng Tian, Min Wang, Jianxiang Wang, Yingchang Mi
Format: Article
Language:English
Published: Wolters Kluwer Health 2023-03-01
Series:Blood Science
Online Access:http://journals.lww.com/10.1097/BS9.0000000000000142

Internet

http://journals.lww.com/10.1097/BS9.0000000000000142

Similar Items