Effect of high-dose intravenous ascorbic acid on microcirculation and endothelial glycocalyx during sepsis and septic shock: a double-blind, randomized, placebo-controlled study

Effect of high-dose intravenous ascorbic acid on microcirculation and endothelial glycocalyx during sepsis and septic shock: a double-blind, randomized, placebo-controlled study

Abstract Previous studies indicate supplemental vitamin C improves microcirculation and reduces glycocalyx shedding in septic animals. Our randomized, double-blind, placebo-controlled trial aimed to investigate whether a high dose of intravenous ascorbic acid (AA) might improve microcirculation and...

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Bibliographic Details
Main Authors: Egle Belousoviene, Zivile Pranskuniene, Egle Vaitkaitiene, Vidas Pilvinis, Andrius Pranskunas
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Anesthesiology
Subjects:
Microcirculation
Ascorbic acid
Endothelial glycocalyx
Antioxidants
Online Access:https://doi.org/10.1186/s12871-023-02265-z

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