The unique allosteric property of crocodilian haemoglobin elucidated by cryo-EM

Abstract The principal effect controlling the oxygen affinity of vertebrate haemoglobins (Hbs) is the allosteric switch between R and T forms with relatively high and low oxygen affinity respectively. Uniquely among jawed vertebrates, crocodilians possess Hb that shows a profound drop in oxygen affi...

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Bibliographic Details
Main Authors: Katsuya Takahashi, Yongchan Lee, Angela Fago, Naim M. Bautista, Jay F. Storz, Akihiro Kawamoto, Genji Kurisu, Tomohiro Nishizawa, Jeremy R. H. Tame
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-49947-x