Inhibition of activin A receptor signalling attenuates age-related pathological cardiac remodelling

Inhibition of activin A receptor signalling attenuates age-related pathological cardiac remodelling

In the heart, ageing is associated with DNA damage, oxidative stress, fibrosis and activation of the activin signalling pathway, leading to cardiac dysfunction. The cardiac effects of activin signalling blockade in progeria are unknown. This study investigated the cardiac effects of progeria induced...

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Bibliographic Details
Main Authors: Nicolas G. Clavere, Ali Alqallaf, Kerry A. Rostron, Andrew Parnell, Robert Mitchell, Ketan Patel, Samuel Y. Boateng
Format: Article
Language:English
Published: The Company of Biologists 2022-05-01
Series:Disease Models & Mechanisms
Subjects:
activin signalling
ageing
dna repair
oxidative stress
heart
Online Access:http://dmm.biologists.org/content/15/5/dmm049424

Internet

http://dmm.biologists.org/content/15/5/dmm049424

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