Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion

Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion

Rapid digestion by proteases limits the application of peptides as therapeutics. One strategy to increase the proteolytic stability of peptides is the modification with fluorinated amino acids. This study presents a systematic investigation of the effects of fluorinated leucine and isoleucine deriva...

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Bibliographic Details
Main Authors: Susanne Huhmann, Anne-Katrin Stegemann, Kristin Folmert, Damian Klemczak, Johann Moschner, Michelle Kube, Beate Koksch
Format: Article
Language:English
Published: Beilstein-Institut 2017-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
fluorinated amino acids
hexafluoroleucine
peptide drugs
protease stability
trifluoroisoleucine
Online Access:https://doi.org/10.3762/bjoc.13.279

Internet

https://doi.org/10.3762/bjoc.13.279

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