Increased prevalence of the founder BRCA1 c.5309G>T and recurrent BRCA2 c.1310_1313delAAGA mutations in breast cancer families from Northerstern region of Morocco: evidence of geographical specificity and high relevance for genetic counseling

Increased prevalence of the founder BRCA1 c.5309G>T and recurrent BRCA2 c.1310_1313delAAGA mutations in breast cancer families from Northerstern region of Morocco: evidence of geographical specificity and high relevance for genetic counseling

Abstract Background Inherited mutations in the breast cancer susceptibility genes BRCA1 and BRCA2 (BRCA1/2) confer high risks of breast and ovarian cancer. Because the contribution of BRCA1/2 germline mutations to BC in the Northeastern population of Morocco remains largely unknown, we conducted thi...

Full description

Bibliographic Details
Main Authors: Rahma Melki, Marouane Melloul, Souria Aissaoui, Tijani EL Harroudi, Noureddine Boukhatem
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Cancer
Subjects:
Breast cancer
BRCA1
BRCA2
Mutation
Moroccan population
Online Access:https://doi.org/10.1186/s12885-023-10822-5

Internet

https://doi.org/10.1186/s12885-023-10822-5

Similar Items