Regulation of Papillary Muscle Contractility by NAD and Ammonia Interplay: Contribution of Ion Channels and Exchangers

Regulation of Papillary Muscle Contractility by NAD and Ammonia Interplay: Contribution of Ion Channels and Exchangers

Various models, including stem cells derived and isolated cardiomyocytes with overexpressed channels, are utilized to analyze the functional interplay of diverse ion currents involved in cardiac automaticity and excitation–contraction coupling control. Here, we used β-NAD and ammonia, known hyperpol...

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Bibliographic Details
Main Authors: Alexey S. Averin, Maxim V. Konakov, Oleg Y. Pimenov, Miliausha H. Galimova, Alexey V. Berezhnov, Miroslav N. Nenov, Vladimir V. Dynnik
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Membranes
Subjects:
cardiomyocytes
papillary muscle
NAD/ammonia antagonism
contractility
electrophysiological characteristics
Kir2.x channels, HCN channels, Ca<sup>2+</sup>-activated K<sup>+</sup> channels
Online Access:https://www.mdpi.com/2077-0375/12/12/1239

Internet

https://www.mdpi.com/2077-0375/12/12/1239

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