Targeting Lactate Dehydrogenase-B as a Strategy to Fight Cancer: Identification of Potential Inhibitors by In Silico Analysis and In Vitro Screening

Targeting Lactate Dehydrogenase-B as a Strategy to Fight Cancer: Identification of Potential Inhibitors by In Silico Analysis and In Vitro Screening

Lactate dehydrogenase (LDH) is an enzyme that catalyzes the reversible conversion of lactate to pyruvate while reducing NAD<sup>+</sup> to NADH (or oxidizing NADH to NAD<sup>+</sup>). Due to its central role in the Warburg effect, LDH-A isoform has been considered a promising...

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Bibliographic Details
Main Authors: Manos Vlasiou, Vicky Nicolaidou, Christos Papaneophytou
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceutics
Subjects:
lactate dehydrogenase-B
cancer
inhibitors
colorimetric assay
molecular dynamics
Online Access:https://www.mdpi.com/1999-4923/15/10/2411

Internet

https://www.mdpi.com/1999-4923/15/10/2411

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