In vivo conversion of rat astrocytes into neuronal cells through neural stem cells in injured spinal cord with a single zinc-finger transcription factor

In vivo conversion of rat astrocytes into neuronal cells through neural stem cells in injured spinal cord with a single zinc-finger transcription factor

Abstract Background Spinal cord injury (SCI) results in glial scar formation and irreversible neuronal loss, which finally leads to functional impairments and long-term disability. Our previous studies have demonstrated that the ectopic expression of Zfp521 reprograms fibroblasts and astrocytes into...

Full description

Bibliographic Details
Main Authors: Masoumeh Zarei-Kheirabadi, Mahdi Hesaraki, Sahar Kiani, Hossein Baharvand
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Stem Cell Research & Therapy
Subjects:
Adult astrocyte
Conversion
Reprogramming
Neural stem cells
Zfp521
In vivo reprogramming
Online Access:https://doi.org/10.1186/s13287-019-1448-x

Internet

https://doi.org/10.1186/s13287-019-1448-x

Similar Items