Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs

Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs

Affinity maturation is often a necessary step for the development of potent therapeutic molecules. Many different diversification strategies have been used for antibody affinity maturation, including error-prone PCR, chain shuffling, and targeted complementary-determining region (CDR) mutation. Alth...

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Bibliographic Details
Main Authors: Andre A. R. Teixeira, Sara D’Angelo, M. Frank Erasmus, Camila Leal-Lopes, Fortunato Ferrara, Laura P. Spector, Leslie Naranjo, Esteban Molina, Tamara Max, Ashley DeAguero, Katherine Perea, Shaun Stewart, Rebecca A. Buonpane, Horacio G. Nastri, Andrew R. M. Bradbury
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:mAbs
Subjects:
Affinity maturation
CDR shuffling
developability
liability
library construction
off-rate
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2022.2115200

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2022.2115200

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