Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence

<p>Abstract</p> <p>Extensive genetic, biochemical, and histological evidence has implicated the amyloid-β peptide (Aβ) in Alzheimer's disease pathogenesis, and several mechanisms have been suggested, such as metal binding, reactive oxygen species production, and membrane pore...

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Bibliographic Details
Main Author: Bredesen Dale E
Format: Article
Language:English
Published: BMC 2009-06-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/4/1/27