Presence of anti-Glomerular basement membrane (GBM) antibodies and Myeloperoxidase anti neutrophilic cytoplasmic antibodies (MPO ANCA) in a case of rapidly progressive glomerulonephritis.
A 69 year old male developed rapid deterioration of kidney function and developed uremic symptoms. Creatinine was 486.2 µmol/L (5.5 mg/dl) on presentation. Anti-MPO was positive (titer>8 units, normal <0.4). He was clinically diagnosed with rapidly proliferative glomerulonephritis (RPGN) most...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00053/full |
| _version_ | 1831674682675298304 |
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| author | Gaurang P Mavani Max ePommier Sandar eWin Michael Frank Michelis Jordan eRosenstock |
| author_facet | Gaurang P Mavani Max ePommier Sandar eWin Michael Frank Michelis Jordan eRosenstock |
| author_sort | Gaurang P Mavani |
| collection | DOAJ |
| description | A 69 year old male developed rapid deterioration of kidney function and developed uremic symptoms. Creatinine was 486.2 µmol/L (5.5 mg/dl) on presentation. Anti-MPO was positive (titer>8 units, normal <0.4). He was clinically diagnosed with rapidly proliferative glomerulonephritis (RPGN) most likely due to ANCA vasculitis. He received three doses of pulse methylprednisone therapy. Kidney biopsy showed pauci-immune glomerulonephritis. Immunofluoroscence was also positive for faint linear staining of glomerular basement membrane. Anti GBM antibody was positive 2.1U (normal <1). He was started on high dose oral steroids, monthly intravenous cyclophosphamide and plasmapharesis was also initiated. His symptoms improved and creatinine is 247.5 µmol/L (2.8mg/dl). His repeat anti GBM antibody was negative. This is a rare case of rapidly progressive glomerulonephritis due to dual MPO-ANCA antibodies and anti GBM antibodies (DAV). |
| first_indexed | 2024-12-20T03:49:07Z |
| format | Article |
| id | doaj.art-33ee58e306b949efa0aa2cf130817c1e |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-20T03:49:07Z |
| publishDate | 2015-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-33ee58e306b949efa0aa2cf130817c1e2022-12-21T19:54:30ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2015-08-01210.3389/fmed.2015.00053141830Presence of anti-Glomerular basement membrane (GBM) antibodies and Myeloperoxidase anti neutrophilic cytoplasmic antibodies (MPO ANCA) in a case of rapidly progressive glomerulonephritis.Gaurang P Mavani0Max ePommier1Sandar eWin2Michael Frank Michelis3Jordan eRosenstock4Lenox Hill hospitalLenox Hill hospitalLenox Hill hospitalLenox Hil HospitalLenox Hill HospitalA 69 year old male developed rapid deterioration of kidney function and developed uremic symptoms. Creatinine was 486.2 µmol/L (5.5 mg/dl) on presentation. Anti-MPO was positive (titer>8 units, normal <0.4). He was clinically diagnosed with rapidly proliferative glomerulonephritis (RPGN) most likely due to ANCA vasculitis. He received three doses of pulse methylprednisone therapy. Kidney biopsy showed pauci-immune glomerulonephritis. Immunofluoroscence was also positive for faint linear staining of glomerular basement membrane. Anti GBM antibody was positive 2.1U (normal <1). He was started on high dose oral steroids, monthly intravenous cyclophosphamide and plasmapharesis was also initiated. His symptoms improved and creatinine is 247.5 µmol/L (2.8mg/dl). His repeat anti GBM antibody was negative. This is a rare case of rapidly progressive glomerulonephritis due to dual MPO-ANCA antibodies and anti GBM antibodies (DAV).http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00053/fullCyclophosphamidePlasmapheresisRPGNAnti -MPO antibodyAnti- GBM antibody |
| spellingShingle | Gaurang P Mavani Max ePommier Sandar eWin Michael Frank Michelis Jordan eRosenstock Presence of anti-Glomerular basement membrane (GBM) antibodies and Myeloperoxidase anti neutrophilic cytoplasmic antibodies (MPO ANCA) in a case of rapidly progressive glomerulonephritis. Frontiers in Medicine Cyclophosphamide Plasmapheresis RPGN Anti -MPO antibody Anti- GBM antibody |
| title | Presence of anti-Glomerular basement membrane (GBM) antibodies and Myeloperoxidase anti neutrophilic cytoplasmic antibodies (MPO ANCA) in a case of rapidly progressive glomerulonephritis. |
| title_full | Presence of anti-Glomerular basement membrane (GBM) antibodies and Myeloperoxidase anti neutrophilic cytoplasmic antibodies (MPO ANCA) in a case of rapidly progressive glomerulonephritis. |
| title_fullStr | Presence of anti-Glomerular basement membrane (GBM) antibodies and Myeloperoxidase anti neutrophilic cytoplasmic antibodies (MPO ANCA) in a case of rapidly progressive glomerulonephritis. |
| title_full_unstemmed | Presence of anti-Glomerular basement membrane (GBM) antibodies and Myeloperoxidase anti neutrophilic cytoplasmic antibodies (MPO ANCA) in a case of rapidly progressive glomerulonephritis. |
| title_short | Presence of anti-Glomerular basement membrane (GBM) antibodies and Myeloperoxidase anti neutrophilic cytoplasmic antibodies (MPO ANCA) in a case of rapidly progressive glomerulonephritis. |
| title_sort | presence of anti glomerular basement membrane gbm antibodies and myeloperoxidase anti neutrophilic cytoplasmic antibodies mpo anca in a case of rapidly progressive glomerulonephritis |
| topic | Cyclophosphamide Plasmapheresis RPGN Anti -MPO antibody Anti- GBM antibody |
| url | http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00053/full |
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