Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo

Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo

The uniqueness of paclitaxel’s antimitotic action mechanism has fueled research toward its application in more effective and safer cancer treatments. However, the low water solubility, recrystallization, and side effects hinder the clinical success of classic paclitaxel chemotherapy. The aim of this...

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Bibliographic Details
Main Authors: Gamze Varan, Cem Varan, Süleyman Can Öztürk, Juan M. Benito, Güneş Esendağlı, Erem Bilensoy
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Nanomaterials
Subjects:
tumor targeting
cyclodextrin
nanoparticle
paclitaxel
biodistribution
breast tumor induced animal model
Online Access:https://www.mdpi.com/2079-4991/11/2/515

Internet

https://www.mdpi.com/2079-4991/11/2/515

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