Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo
The uniqueness of paclitaxel’s antimitotic action mechanism has fueled research toward its application in more effective and safer cancer treatments. However, the low water solubility, recrystallization, and side effects hinder the clinical success of classic paclitaxel chemotherapy. The aim of this...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/2/515 |
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| author | Gamze Varan Cem Varan Süleyman Can Öztürk Juan M. Benito Güneş Esendağlı Erem Bilensoy |
| author_facet | Gamze Varan Cem Varan Süleyman Can Öztürk Juan M. Benito Güneş Esendağlı Erem Bilensoy |
| author_sort | Gamze Varan |
| collection | DOAJ |
| description | The uniqueness of paclitaxel’s antimitotic action mechanism has fueled research toward its application in more effective and safer cancer treatments. However, the low water solubility, recrystallization, and side effects hinder the clinical success of classic paclitaxel chemotherapy. The aim of this study was to evaluate the in vivo efficacy and biodistribution of paclitaxel encapsulated in injectable amphiphilic cyclodextrin nanoparticles of different surface charges. It was found that paclitaxel-loaded amphiphilic cyclodextrin nanoparticles showed an antitumoral effect earlier than the drug solution. Moreover, the blank nanoparticles reduced the tumor growth with a similar trend to the paclitaxel solution. At 24 h, the nanoparticles had not accumulated in the heart and lungs according to the biodistribution assessed by in vivo imaging. Therefore, our results indicated that the amphiphilic cyclodextrin nanoparticles are potentially devoid of cardiac toxicity, which limits the clinical use and commercialization of certain polymeric nanoparticles. In conclusion, the amphiphilic cyclodextrin nanoparticles with different surface charge increased the efficiency of paclitaxel in vitro and in vivo. Cyclodextrin nanoparticles could be a good candidate vehicle for intravenous paclitaxel delivery. |
| first_indexed | 2024-03-09T00:46:29Z |
| format | Article |
| id | doaj.art-33f08c038c9949d1830a4b22740bf951 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T00:46:29Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-33f08c038c9949d1830a4b22740bf9512023-12-11T17:28:25ZengMDPI AGNanomaterials2079-49912021-02-0111251510.3390/nano11020515Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In VivoGamze Varan0Cem Varan1Süleyman Can Öztürk2Juan M. Benito3Güneş Esendağlı4Erem Bilensoy5Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, TurkeyDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, TurkeyResearch and Application Center for Advanced Technologies (HUNITEK), Hacettepe University, 06100 Ankara, TurkeyInstitute for Chemical Research, Consejo Superior de Investigaciones Científicas (CSIC), University of Sevilla, Av. Américo Vespucio 49, 41092 Sevilla, SpainCancer Institute, Department of Basic Oncology, Hacettepe University, 06100 Ankara, TurkeyDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, TurkeyThe uniqueness of paclitaxel’s antimitotic action mechanism has fueled research toward its application in more effective and safer cancer treatments. However, the low water solubility, recrystallization, and side effects hinder the clinical success of classic paclitaxel chemotherapy. The aim of this study was to evaluate the in vivo efficacy and biodistribution of paclitaxel encapsulated in injectable amphiphilic cyclodextrin nanoparticles of different surface charges. It was found that paclitaxel-loaded amphiphilic cyclodextrin nanoparticles showed an antitumoral effect earlier than the drug solution. Moreover, the blank nanoparticles reduced the tumor growth with a similar trend to the paclitaxel solution. At 24 h, the nanoparticles had not accumulated in the heart and lungs according to the biodistribution assessed by in vivo imaging. Therefore, our results indicated that the amphiphilic cyclodextrin nanoparticles are potentially devoid of cardiac toxicity, which limits the clinical use and commercialization of certain polymeric nanoparticles. In conclusion, the amphiphilic cyclodextrin nanoparticles with different surface charge increased the efficiency of paclitaxel in vitro and in vivo. Cyclodextrin nanoparticles could be a good candidate vehicle for intravenous paclitaxel delivery.https://www.mdpi.com/2079-4991/11/2/515tumor targetingcyclodextrinnanoparticlepaclitaxelbiodistributionbreast tumor induced animal model |
| spellingShingle | Gamze Varan Cem Varan Süleyman Can Öztürk Juan M. Benito Güneş Esendağlı Erem Bilensoy Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo Nanomaterials tumor targeting cyclodextrin nanoparticle paclitaxel biodistribution breast tumor induced animal model |
| title | Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo |
| title_full | Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo |
| title_fullStr | Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo |
| title_full_unstemmed | Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo |
| title_short | Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo |
| title_sort | therapeutic efficacy and biodistribution of paclitaxel bound amphiphilic cyclodextrin nanoparticles analyses in 3d tumor culture and tumor bearing animals in vivo |
| topic | tumor targeting cyclodextrin nanoparticle paclitaxel biodistribution breast tumor induced animal model |
| url | https://www.mdpi.com/2079-4991/11/2/515 |
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