Trogocytosis and fratricide killing impede MSLN-directed CAR T cell functionality

Trogocytosis and fratricide killing impede MSLN-directed CAR T cell functionality

Successful translation of chimeric antigen receptor (CAR) T cell therapy for the treatment of solid tumors has proved to be troublesome, mainly due to the complex tumor microenvironment promoting T cell dysfunction and antigen heterogeneity. Mesothelin (MSLN) has emerged as an attractive target for...

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Bibliographic Details
Main Authors: Esther Schoutrop, Stefanie Renken, Isabella Micallef Nilsson, Paula Hahn, Thomas Poiret, Rolf Kiessling, Stina L Wickström, Jonas Mattsson, Isabelle Magalhaes
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
CAR T cells
mesothelin
trogocytosis
ovarian cancer
immune escape
fratricide killing
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2093426

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2022.2093426

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