Blocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection.

Blocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection.

Persistent production of type I interferon (IFN) by activated plasmacytoid dendritic cells (pDC) is a leading model to explain chronic immune activation in human immunodeficiency virus (HIV) infection but direct evidence for this is lacking. We used a dual antagonist of Toll-like receptor (TLR) 7 an...

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Bibliographic Details
Main Authors: Muhamuda Kader, Amanda P Smith, Cristiana Guiducci, Elizabeth R Wonderlich, Daniel Normolle, Simon C Watkins, Franck J Barrat, Simon M Barratt-Boyes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3723633?pdf=render

Internet

http://europepmc.org/articles/PMC3723633?pdf=render

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